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马红武，博士，中国科学院天津工业生物技术研究所研究员，博士生（硕士生）导师。

主讲课程：

本科生：合成生物学导论

研究生：工业生物技术，计算系统生物学

科研领域及方向

[1] 基因组规模代谢网络构建和结构功能分析

[2] 代谢途径设计和代谢工程改造靶点预测

[3] 代谢途径和基因回路动力学模型

[4] 计算系统生物学软件和网站开发

科研项目情况

[1] 973计划：基于网络分析的DNA模块设计与组装，2012-2016

[2] 863计划：生化网络重构与维生素生产新菌种,2012-2015

[3] 天津科技支撑计划重点项目：数据和模型相结合的生物产品代谢途径设计的研究，2014-2017

[4] 中科院重点部署项目: 新型固碳途径设计与构建, 2016-2018

[5] 国家合成生物专项：模式微生物数字细胞建模、分析与设计，2019-2023

主要学术成果

先后发表各类科研论文40余篇，授权发明专利3项。发表的主要学术论文有：

1. Zhitao, M.; Hongwu, M., iMTBGO: An Algorithm for Integrating Metabolic Networks with Transcriptomes Based on Gene Ontology Analysis. Current Genomics 2019, 20 (4), 252-259.

2. Yang, X.; Yuan, Q.; Luo, H.; Li, F.; Mao, Y.; Zhao, X.; Du, J.; Li, P.; Ju, X.; Zheng, Y.; Chen, Y.; Liu, Y.; Jiang, H.; Yao, Y.; Ma, H.; Ma, Y., Systematic design and in vitro validation of novel one-carbon assimilation pathways. Metabolic engineering 2019, 56, 142-153.

3. Wang, Y.; Liu, Y.; Li, J.; Yang, Y.; Ni, X.; Cheng, H.; Huang, T.; Guo, Y.; Ma, H.; Zheng, P.; Wang, M.; Sun, J.; Ma, Y., Expanding targeting scope, editing window, and base transition capability of base editing in Corynebacterium glutamicum. Biotechnology and bioengineering 2019, 116 (11), 3016-3029.

4. Lu, X.; Liu, Y.; Yang, Y.; Wang, S.; Wang, Q.; Wang, X.; Yan, Z.; Cheng, J.; Liu, C.; Yang, X.; Luo, H.; Yang, S.; Gou, J.; Ye, L.; Lu, L.; Zhang, Z.; Guo, Y.; Nie, Y.; Lin, J.; Li, S.; Tian, C.; Cai, T.; Zhuo, B.; Ma, H.; Wang, W.; Ma, Y.; Liu, Y.; Li, Y.; Jiang, H., Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design. Nature communications 2019, 10 (1), 1378.

5. Liu, D.; Sun, H.; Ma, H., Deciphering Microbiome Related to Rusty Roots of Panax ginseng and Evaluation of Antagonists Against Pathogenic Ilyonectria. Frontiers in microbiology 2019, 10, 1350.

6. Cui, Z., Zhao, Y. , Mao, Y. , Shi, T. , Lu, L. , Ma, H. , Wang, Z. and Chen, T. , In vitro biosynthesis of optically pure d‐(−)‐acetoin from meso‐2,3‐butanediol using 2,3‐butanediol dehydrogenase and NADH oxidase. J. Chem. Technol. Biotechnol. 2019, 94, 8.

7. Zheng, Y.; Yuan, Q.; Luo, H.; Yang, X.; Ma, H., Engineering NOG-pathway in Escherichia coli for poly-(3-hydroxybutyrate) production from low cost carbon sources. Bioengineered 2018, 9 (1), 209-213.

8. Zhang, S.; Liu, D.; Mao, Z.; Mao, Y.; Ma, H.; Chen, T.; Zhao, X.; Wang, Z., Model-based reconstruction of synthetic promoter library in Corynebacterium glutamicum. Biotechnology letters 2018, 40 (5), 819-827.

9. Liu, D.; Mao, Z.; Guo, J.; Wei, L.; Ma, H.; Tang, Y.; Chen, T.; Wang, Z.; Zhao, X., Construction, Model-Based Analysis, and Characterization of a Promoter Library for Fine-Tuned Gene Expression in Bacillus subtilis. ACS synthetic biology 2018, 7 (7), 1785-1797.

10. Li, F.; Xie, W.; Yuan, Q.; Luo, H.; Li, P.; Chen, T.; Zhao, X.; Wang, Z.; Ma, H., Genome-scale metabolic model analysis indicates low energy production efficiency in marine ammonia-oxidizing archaea. AMB Express 2018, 8 (1), 106.

11. Zheng, Y.; Yuan, Q.; Yang, X.; Ma, H., Engineering Escherichia coli for poly-(3-hydroxybutyrate) production guided by genome-scale metabolic network analysis. Enzyme and microbial technology 2017, 106, 60-66.

12. Yuan, Q.; Huang, T.; Li, P.; Hao, T.; Li, F.; Ma, H.; Wang, Z.; Zhao, X.; Chen, T.; Goryanin, I., Pathway-Consensus Approach to Metabolic Network Reconstruction for Pseudomonas putida KT2440 by Systematic Comparison of Published Models. PloS one 2017, 12 (1), e0169437.

14. Yang, X.; Yuan, Q.; Zheng, Y.; Ma, H.; Chen, T.; Zhao, X., An engineered non-oxidative glycolysis pathway for acetone production in Escherichia coli. Biotechnology letters 2016, 38 (8), 1359-65.

 

15. Meng, Q.; Zhang, Y.; Ju, X.; Ma, C.; Ma, H.; Chen, J.; Zheng, P.; Sun, J.; Zhu, J.; Ma, Y.; Zhao, X.; Chen, T., Production of 5-aminolevulinic acid by cell free multi-enzyme catalysis. Journal of biotechnology 2016, 226, 8-13.

授权发明专利主要有：

马红武，郑阳阳，一种筛选高产苏氨酸菌株的方法。CN103981206A ZL201410246839.3

马红武，杨雪，袁倩倩，江会峰，利用乙醇醛合成乙酰辅酶A及其衍生产品的新途径，201611167145.6

马红武，刘德飞，一种用于防治人参红皮病的微生物及应用，201711111107.3

郑平，曹国强，马红武，张彦飞，孙际宾，马延和。一种提高L-苏氨酸转化率的方法及其应用。CN 105505969A ZL201410504828

获奖情况

因代谢网络模型构建与结构分析方面的研究成果获天津市自然科学奖二等奖（第二完成人）及汤森路透计算机科学领域高被引科学家奖

联系方式

办公地点：天津空港经济区西七道32号中科院天津工业生物技术研究所

邮政编码：300308

办公电话：022-24828735

 

Email： ma_hw AT tib.cas.cn