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柏文琴，博士，中国科学院天津工业生物技术研究所研究员，博士生（硕士生）导师。

科研领域及方向

[1] 天然高分子材料的微生物合成与应用

[2] 活性多糖的微生物合成与应用

[3] 设计构建蛋白纳米支架，组装多酶反应器，实现高附加值化合物的体内外合成。

科研项目情况

[1] 国家自然科学青年基金项目，11家族木聚糖酶嗜碱机制研究，2015-2017

[2] 天津市合成生物技术创新能力提升行动“地方科技攻关”项目，基于丝蛋白功能材料的设计与合成，2020-2023

主要学术成果

先后发表各类科研论文20余篇，授权发明专利3项。发表的主要学术论文有：

[1] Wenqin Bai, Cameron J. Sargent, Jeong-Mo Choi, Rohit V. Pappu, Fuzhong Zhang*. Covalently-assembled single-chain protein nanostructures with ultra-high stability. Nature Communications. 2019, 10, 3317.

[2] Wenqin Bai, Weitao Geng, Shaojie Wang and Fuzhong Zhang*. Biosynthesis, regulation, and engineering of microbially produced branched biofuels. Biotechnology for Biofuels. 2019, 12:84

[3] Wenqin Bai, Yi-Shu Tai, Jingyu Wang, Jilong Wang, Pooja Jambunathan, Kevin J. Fox, Kechun Zhang*. Engineering Nonphosphorylative Metabolism to Synthesize Mesaconate from D-Xylose and L-Arabinose in Escherichia coli. Metabolic Engineering, 2016 (38): 285–292

[4] Wenqin Bai*, Yufan Cao, Jun Liu, Qinhong Wang, Zhenhu Jia. Improvement of alkalophilicity of an alkaline xylanase Xyn11A-LC from Bacillus sp. SN5 by random mutation and Glu135 saturation mutagenesis. BMC Biotechnology, 2016(16):77

[5] Wenqin Bai, Yanfen Xue, Yueju Zhao, Qinhong Wang, Yanhe Ma*. Structural insight into and mutational analysis of family 11 xylanases: implications for mechanisms of higher pH catalytic adaptation. PLoS One. 2015, Jul 10, 10(7):e0132834.

[6] Wenqin Bai, Yanfen Xue, Cheng Zhou, Yanhe Ma*. Cloning, expression and characterization of an alkali-tolerant xylanase from alkalophilic Bacillus sp. SN5. Biotechnol Appl Biochem. 2015, 62(2):208-17

[7] Wenqin Bai, Cheng Zhou, Yanfen Xue, Chunhsiang Huang, Ruiting Guo, Yanhe Ma*. Three-dimensional structure of an alkaline xylanase Xyn11A-LC from alkalophilic Bacillus sp. SN5 and improvement of its thermal performance by introducing arginines substitutions. Biotechnol Lett. 2014, 36(7):1495-501.

[8] Wenqin Bai, Yanfen Xue, Cheng Zhou, Yanhe Ma*. Cloning, expression and characterization of a novel salt-tolerant xylanase from Bacillus sp. SN5. Biotechnol Lett. 2012, 34(11):2093-9.

授权发明专利主要有：

1.  马延和、柏文琴、薛燕芬。一种碱性木聚糖酶及其编码基因与应用。 ZL201110317121.5

2.  马延和、柏文琴、薛燕芬。一种耐盐木聚糖酶及其编码基因与应用。ZL201110317110.7

3.  邱星辉、柏文琴、李梅、何风琴。一株可高效降解有机磷农药的降解菌及其用途。ZL200410081019X

联系方式

办公地点： 天津市空港经济区西七道32号中国科学院天津工业生物技术研究所A507

邮政编码：300308

办公电话：022-84861999

 

Email： baiwq@tib.cas.cn