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朱蕾蕾，博士，中国科学院天津工业生物技术研究所研究员，博士生（硕士生）导师。天津市青年科技工作者协会会员代表。
主讲课程
研究生：工业生物技术
主要教学研究及成果情况
参编专著1部。
[1] Zhu L., Arlt M., Liu H., Schwaneberg U. Chapter 3: Channel protein FhuA as a promising biomolecular scaffold for bioconjugates. Bio-Synthetic Hybrid Materials and Bionanoparticles: A Biological Chemical Approach Towards Material Science. Royal Society of Chemistry,ISBN 9781849738224,2015.
科研领域及方向
[1]聚焦酶蛋白进化设计，发展先进的酶分子改造方法和高通量筛选技术
[2]创制高性能的工业酶和蛋白质，应用于重要化学品的绿色生物制造
科研项目情况
[1] 1. 合成生物学重点研发计划：难降解有毒污染物智能生物降解体系，2019-2024
[2] 国家自然科学基金面上项目：谷氨酸外排蛋白的结构功能关系与性能提升研究，2021-2024
[3] 天津市合成生物技术创新能力提升行动：新一代酶制剂真核表达体系，2020-2022.
[4] 天津市自然科学基金：脂肪酶的表面活性剂耐受性研究，2019-2022
[5] 中科院STS项目:污染场地生物修复与塑料废弃物处置技术研究与示范，2019-2020
[6] 中科院重点部署项目：二氧化碳的人工生物合成子课题，2017-2019
[7] 中国科学院-诺和诺德基金：Protein engineering of methionine aminopeptidase (MAP) for robust N-terminal methionine removal from 2018-2020
主要学术成果
先后发表各类科研论文30余篇，申请发明专利10项。代表性学术论文有：
[1] Shi L., Liu H, Gao S., Weng Y.*, Zhu L.*.Enhanced extracellular production of IsPETase in Escherichia coli via engineering of the pelB signal peptide. Journal of Agricultural and Food Chemistry. 2021,DOI：10.1021/acs.jafc.0c07469.
[2] Li T., Tang Z., Wei H., Tan Z., Liu P., Li J., Zheng Y., Lin J., Liu W., Jiang H., Liu H.*, Zhu L.*, Ma Y. Totally atom-economical synthesis of lactic acid from formaldehyde: combined bio-carboligation and chemo-rearrangement without the isolation of intermediate. Green Chemistry, 2020, 22: 6809-6814.
[3] Cheng C., Haider J., Liu P., Yang J., Tan Z., Huang T., Lin J., M. J.*, Liu H.*, Zhu L.*. Engineered LPMO significantly boosting cellulase-catalyzed depolymerization of cellulose. Journal of Agricultural and Food Chemistry. 2020, 68: 15257−15266.
[4] Cheng F., Yang J., Schwaneberg U., Zhu L. Rational surface engineering of an arginine deiminase (an antitumor enzyme) for increased PEGylation efficiency. Biotechnology and Bioengineering, 2019, 116(9): 2156-2166.
[5] Cheng F., Yang J., Bocola M., Schwaneberg U., Zhu L. Loop engineering reveals the importance of active-site-decorating loops and gating residue in substrate affinity modulation of arginine deiminase (an anti-tumor enzyme).Biochemical and Biophysical Research Communication. 2018, 499(2): 233-238.
[6] Frauenkron‑Machedjou V. J., Fulton A., Zhao J., Weber L., Jaege K.‑E. r, Schwaneberg U., and Zhu L., Exploring the full natural diversity of single amino acid exchange reveals that 40-60% of BSLA positions improve organic solvents resistance. Bioresource and Bioprocessing, 2018, 5:2.
[7] Cheng F.*, Zhu L.*, Schwaneberg U. Directed evolution 2.0: improving and deciphering enzyme properties. Chemical Communication, 2015,51(48):9760-9772.
[8] Cheng F., Kardashliev T., Pitzler C., Shehzad A, Lue H., Bernhagen J, Zhu L. #, Schwaneberg U#. A competitive flow cytometry screening system for directed evolution of therapeutic enzyme. ACS Synthetic Biology, 2015, 4 (7):768-775.
联系方式
办公地点：天津空港经济区西七道32号
邮政编码：300308
办公电话：022-24828796
Email： zhu_ll@tib.cas.cn