澳门威泥斯人-官方app下载

李玉银，博士，澳门威泥斯人助理研究员。2012 年毕业于东北师范大学药物基因和蛋白筛选国家工程实验室。天津市“131”人才计划第三层次人选。

主讲课程：
本科生：《毒理学》、《制药工程工艺实验》

主要教学研究及成果情况
[1] 第四届“互联网+”大学生创新创业大赛澳门威泥斯人官方网站校赛二等奖，2017.08-2018.08，指导教师
[2] 国家级大学生创新创业训练计划项目：核桃楸果提取物的抗肿瘤活性研究，2013.05-2014.05，指导教师

科研领域及方向
[1] 新型抗肿瘤靶向药物的筛选和分子药理学研究；
[2] 利用微生物发酵和细胞培养技术制备蛋白质药物。

科研项目情况
[1] 国家自然科学基金项目：Nedd4泛素连接酶小分子化合物抑制剂的筛选和抗肿瘤活性研究，2015.01-2017.12（主持人）
[2] 工业发酵微生物教育部重点实验室主任基金：大肠杆菌中高效表达抗肿瘤蛋白大豆胰蛋白酶抑制剂BBI及制备工艺优化，2013.10-2015.09（主持人）
[3] 澳门威泥斯人官方网站科学研究基金：Nedd4泛素连接酶小分子抑制剂抗肿瘤活性及其作用机制研究，2014.01-2015.06（主持人）

主要学术成果
[1] Li Yuyin, Pan Guojun, Chen Yue, Yang Qian, Hao Tiantian, Zhao Lianbo, Zhao Long, Cong Yusheng, Diao Aipo*,Yu Peng*, Inhibitor of the human telomerase reverse trancriptase (hTERT) gene promoter induces cell apoptosis via a mitochondrial-dependent pathway [J], European Journal of Medicinal Chemistry, 2018, 145: 370-378.
[2] Luo Shenheng, Jing Lei, Zhao Tian, Li Yuyin, Liu Zhenxing, Diao Aipo*. Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking [J]. Sci Rep, 2017, 7:42668.
[3] Li Yuyin, Sun Yuejun, Jing Lifang, Wang Jianjun, Yan Yali, Feng Yajuan, Zhang Yueying, Liu Zhenxing, Ma Long, Diao Aipo*. Lysosome Inhibitors Enhance the Chemotherapeutic Activity of Doxorubicin in HepG2 Cells [J]. Chemotherapy, 2017, 62(2):85-93.
[4] Li Yuyin, Guo Ailong, Feng Yajuan, Zhang Yueying, Wang Jianjun, Jing Lifang, Yan Yali, Jing lei, Liu Zhenxing, Ma Long, Diao Aipo*. Sp1 transcription factor promotes TMEPAI gene expression and contributes to cell proliferation [J]. Cell Prolif, 2016, 49(6):710-719.
[5] Luo Shenheng, Yang Meng, Lv Dan, Jing Lei, Li Yuyin, Liu Zhenxing, Diao Aipo*. TMEPAI increases lysosome stability and promotes autophagy [J]. Int J Biochem Cell Biol, 2016, 76:98-106.
[6] Li Yuyin, Zhang Li, Zhou Jie, Luo Shenheng, Huang Rui, Zhao Changcai, Diao Aipo*. Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy [J]. Cell Prolif, 2015, 48(3):338-347.
[7] Ailong Guo, Ping Qin, Weiwei Shi, Yuyin Li*, Aipo Diao*, Cloning and characterization of the TMEPAI gene promoter [J], Lecture Notes in Electrical Engineering, 2015, 333:67-73.  
[8] Kunyuan Kou, Jianli Dang, Baoxia Zhang, Guanrong Wu, Yuyin Li*, Aipo Diao*, Establishment of a Method to Measure the Interaction Between Nedd4 and UbCH5c for Drug Screening [J], Lecture Notes in Electrical Engineering, 2015, 332:297-303.
[9] Changcai Zhao, Xing Niu, Rui Huang, Jiali Dong, Yuyin Li*, Aipo Diao*, Effect of Manchurian Walnut Extracts on Cancer Cells Proliferation [J], Lecture Notes in Electrical Engineering, 2015, 332:533-539.
[10] Bai Xilong, Jing Lei, Li Yinchuan, Li Yuyin, Luo Shenheng, Wang Shasha, Zhou Jie, Liu Zhe, Diao Aipo*. TMEPAI inhibits TGF-beta signaling by promoting lysosome degradation of TGF-beta receptor and contributes to lung cancer development [J]. Cell Signal, 2014, 26(9):2030-2039.
[11] Li Yuyin, Bao Yongli*, Song Zhenbo, Sun Luguo, Wu Ping, Zhang Yu, Fan Cong, Huang Yanxin, Wu Yin, Yu Chunlei, Sun Ying, Zheng Lihua, Wang Guannan, Li Yuxin*. The threonine protease activity of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation [J]. PLoS One, 2012, 7(5):e35030.

联系方式
办公地点：天津经济技术开发区第十三大街29号澳门威泥斯人
邮政编码：300457
办公电话：022-60602948
传 真：022-60602298
Email： liyuyin@tust.edu.cn