澳门威泥斯人-官方app下载

薛鲜丽，博士，澳门威泥斯人讲师。

主讲课程：
本科生：《普通生物学》《生物工程专业英语》《生物分离工程》《酿酒作物学》
研究生：《微生物遗传与育种》

主要教学研究及成果情况

科研领域及方向
[1] 生产衣康酸等有机酸工业菌株的构建及改良
[2] 丝状真菌表达系统的遗传改造

科研项目情况
[1] 国家自然科学基金青年科学基金项目，31902193，里氏木霉中调控Caldicellulosiruptor bescii双功能木聚糖酶/纤维素酶CbXyn10C高效表达的关键分子的筛选与鉴定，2020/01-2022/12 主持
[2] 国家自然科学基金面上项目,31672458,多结构域双功能纤维素酶/木聚糖酶CbXyn10C/Cel48B底物特异性的分子机制研究,2017/01-2020/12 参与者
[3] 国家自然科学基金青年科学基金项目,31400067,多基因协同调控里氏木霉高效分泌表达蛋白的研究,2015/01-2017/12 参与者

主要学术成果
先后发表各类科研论文17篇，授权发明专利2项。发表的主要学术论文有：
[1] Xianli Xue, Boya Liu, Zijun Gao, Wangdepei. Research status and development of global transcriptional regulators in filamentous fungi (in Chinese). Food Research and Development. 2020, 21: 199-207
[2] Xianhua Sun, Xianli Xue, Mengzhu Li, Fei Gao, Zhenzhen Hao, Huoqing Huang, Huiying Luo, Lina Qin*, Bin Yao*, Xiaoyun Su*, Efficient Coproduction of Mannanase and Cellulase by the Transformation of a Codon-Optimized Endomannanase Gene from Aspergillus niger into Trichoderma reesei, Journal of Agricultural and Food Chemistry, 2017, 65(50): 11046-11053
[3] Yindi Chu, Tao Tu, Leena Penttinen, Xianli Xue, Xiaoyu Wang, Zhuolin Yi, Li Gong, Juha Rouvinen, Huiying Luo, Nina Hakulinen, Bin Yao, Xiaoyun Su. Insights into the roles of non-catalytic residues in the active site of a GH10 xylanase with activity on cellulose. J Biol Chem. 2017, 292(47):19315-19327
[4] Yilan Wu, Xianhua Sun, Xianli Xue, Huiying Luo, Bin Yao, Xiangming Xie, Xiaoyun Su. Overexpressing key component genes of the secretion pathway for enhanced secretion of an Aspergillus niger glucose oxidase in Trichoderma reesei. Enzyme and Microbial Technology. 2017.106: 83–87
[5] Wu Yilan, Xue Xianli, Xie Xiangming, Su Xiaoyun.Expression of a Glucose Oxidase from Aspergillus niger in Trichoderma reesei and its Effects on Production of Endogeneous Cellulases (in Chinese). Jounarl of Agricultural Science and Technology, 2017, 19 (5): 42－50
[6] Xianli Xue, Yilan Wu, Xing Qin, Rui Ma, Huiying Luo, Xiaoyun Su, Bin Yao. Revisiting Overexpression of a Heterologous β-glucosidase in Trichoderma reesei: Fusion Expression of the Neosartorya fischeri Bgl3A to cbh1 Enhances the Overall as well as Individual Cellulase Activities, Microbial Cell Factories, 2016, 15: 122.
[7] Wang Rong, Gong Li, Yao Bin, Xue Xianli, Luo Huiying, Zhang Jie, Su Xiaoyun. Improving cellulase expression of Trichoderma reesei by RNAi-mediated repression of cre1 transcription (in Chinese). Journal of food industry science and technology. 2016，37（11）
[8] Rong Wang, Li Gong, Xianli Xue, Xing Qin, Rui Ma, Huiying Luo, Yong jie Zhang, Bin Yao, Xiaoyun Su. Identification of the C-Terminal GH5 Domain from CbCel9B/Man5A as the First Glycoside Hydrolase with Thermal Activation Property from a Multimodular Bifunctional Enzyme. PLoS ONE. 2016. 11(6): e0156802
[9] Xianli Xue, Rong Wang, Tao Tu, Pengjun Shi, Rui Ma, Huiying Luo, Bin Yao, Xiaoyun Su, The N-Terminal GH10 Domain of a Multimodular Protein from Caldicellulosiruptor bescii Is a Versatile Xylanase/β-Glucanase That Can Degrade Crystalline Cellulose, Applied and Environmental Microbiology, 2015, 81(11): 3823-3833
[10] Di Liang, Li Gong , Bin Yao, Xianli Xue, Xing Qin, Rui Ma, Huiying Luo, Xiangming Xie, Xiaoyun Su. Implication of a galactomannan-binding GH2 b -mannosidase in mannan utilization by Caldicellulosiruptor bescii. Biochemical and Biophysical Research Communications. 2015. 467: 334e340
[11] Xianli Xue, Liwen Wang, Yeyu Chen, Xinshang Zhang, Huiying Luo, Zhongyuan Li, Heng Zhao*, Bin Yao*, Identification and Molecular Characterization of an Akirin2 Homolog in Chinese Loach (Paramisgurnus dabryanus), Fish & Shellfish Immunology, 2014, 36(2): 435-443
[12] Zhongyuan Li#, Xianli Xue#, Heng Zhao*, Peilong Yang, Huiying Luo, Junqi Zhao, Huoqing Huang, Bin Yao, A C-Terminal Proline-Rich Sequence Simultaneously Broadens the Optimal Temperature and pH Ranges and Improves the Catalytic Efficiency of Glycosyl Hydrolase Family 10 Ruminal Xylanases, Applied and Environmental Microbiology, 2014, 80(11): 3426-3432

授权发明专利主要有：
[1] Su Xiaoyun, Yao Bin, Xue Xianli, Shi Pengjun, Luo Huiying, Huang huoqing, Wang Yaru, Bai Yingguo, Yang Peilong. Mutated bifunctional xylanase/cellulase improving specificity of cellulose substrates, and the genes and applications. Application number: 201510054287.0
[2] Yao Bin, Su Xiaoyun, Xue Xianli, Luo Huiying, Wang Yaru, Huang huoqing, Bai Yingguo. A method to improve cellulase activity of Trichoderma reesei. Application number: 20151118

联系方式
办公地点：天津经济技术开发区第十三大街29号澳门威泥斯人
邮政编码：300457
办公电话：022-60600127
传 真：022-60602298
Email： xuexianli@tust.edu.cn