澳门威泥斯人欢迎您!
副教授

澳门威泥斯人-官方app下载


何红鹏博士,副教授,硕士生导师。中国细胞生物学学会会员


教育及工作经历

2012.7 -,澳门威泥斯人官方网站,澳门威泥斯人,副教授

2008.5-2011.12,新加坡科技局(A-STAR)分子与细胞生物学研究所(IMCB),博士后研究员(research fellow

2003.1–2008.5,新加坡国立大学,医学院微生物系,博士

2000.7-2002.12,天津医科大学总医院,住院医师

1997.9–2000.7,天津医科大学,核医学与影像医学,硕士

1992.9–1997.7,大连医科大学,临床医疗,学士

主讲课程

本科生:《细胞生物学》,《科技英语》

科研领域及方向

主要致力于利用分子生物学和表观遗传学的方法研究基因的表达调控及其与疾病的关系。同时,研究各种小分子药物,如HDAC抑制剂等的抗肿瘤作用及其分子机制。

人乳头瘤病毒(HPV)相关宫颈癌研究,具体方向包括:

[1] 宫颈癌细胞中HPV病毒基因转录的调控机制。

[2] HVP病毒蛋白和宿主细胞的相互作用。

[3] HPV病毒蛋白对肿瘤相关长链非编码RNA表达的影响。

乳腺癌发病机制研究主要关注乳腺癌转移机制,具体方向包括:

[4] 转录辅助因子MRTF-Ap300对乳腺癌转移的影响及分子细胞生物学机制。

[5]长链非编码RNA HOTAIR对肿瘤转移的影响及其表达调控机制。

[6]小分子药物对乳腺癌细胞的影响

科研情况

目前主持的课题:

[1] 国家自然基金-青年基金,项目编号31301073,项目名称为“HeLa细胞中人乳头瘤病毒E6/E7基因转录的表观遗传学调控机制,起止时间:20141月至201612月。

[2] 天津市科委应用基础与前沿技术研究计划一般项目, 项目编号13JCYBJC38000,项目名称宫颈癌相关高危型HPV E6/E7病毒癌基因转录调控机制,起止时间:201310月至20169月。

[3] 澳门威泥斯人官方网站人才引进基金,2012

代表性论文

1. Hongpeng HE, Fa-Xing YU, Chi SUN, Yan LUO. CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes. PLoS One. 2011; 6(7):e22088. Epub 2011 Jul 15.

2. Hongpeng HE* and Yan LUO*. Brg1 regulates the transcription of human papillomavirus type 18 E6 and E7 genes. Cell Cycle. 2012 Feb 1;11(3).

3. Hongpeng HE, Mei-Chin LEE, Li-Ling ZHENG, Lei ZHENG, Yan LUO*. Integration of the Metabolic/Redox State, Histone Gene Switching, DNA Replication and S-phase Progression by Moonlighting Metabolic Enzymes. Biosci Rep. 2013 33(2),

4. He Hongpeng, Liu X, Wang D, Wang Y, Liu L, Zhou H, Luo X, Wang N, Ji B, Luo Y, Zhang T. SAHA inhibits the transcription initiation of HPV18 E6/E7 genes in HeLa cervical cancer cells. Gene. 2014 Oct 6. v553 (2014) p98–104.

5. He Hongpeng, Wang D, Yao H, Wei Z, Lai Y, Hu J, Liu X, Wang Y, Zhou H, Wang N, Luo XG, Zhang TC. Transcriptional factors p300 and MRTF-A synergistically enhance the expression of migration-related genes in MCF-7 breast cancer cells. Biochem Biophys Res Commun. 2015 Oct 19.v467:813-820.

6. Xing-Hua Liao(#)Li Zheng(#)Hong-Peng He(#)De-Liang ZhengZhao-Qiang WeiNan WangJian DongWen-Jian MaTong-Cun ZhangSTAT3 regulated ATR via microRNA-383 to control DNA damage to affect apoptosis in A431 cellsCellular Signalling20152711):2285-2295.

7. Tin Fan CHAI, YC LECK, Hongpeng HE, Fa-Xing YU, Yan LUO*, Thilo HAGEN*. Hypoxia-inducible factor independent down-regulation of thioredoxin-interacting protein in hypoxia. FEBS Lett. 585(3):492-8. 2011

8. Fa-Xing YU, Tin Fan CHAI, Hongpeng HE, Thilo HAGEN, Yan LUO*. Thioredoxin-interacting protein (Txnip) gene expression: sensing oxidative phosphorylation status and glycolytic rate. J Biol Chem. 285(33):25822-30. 2010

9. Tin Fan CHAI, SY HONG, Hongpeng HE, Li-Ling ZHENG, Thilo HAGEN, Yan LUO, Fa-Xing YU*. A potential mechanism of metformin-mediated regulation of glucose homeostasis: inhibition of Thioredoxin-interacting protein (Txnip) gene expression. Cell Signal. 24(8):1700-5. 2012

10. Li Man, Wang Nan, Gong Hui-Qin, Li Wei-Zong, Liao Xing-Hua, Yang Xiao-Long, He Hong-Peng, Cao Dong-Sun, Zhang Tong-Cun. Ca²⁺ signal-induced cardiomyocyte hypertrophy through activation of myocardin. Gene. 2015 Feb 15;557(1):43-51.

11. Jian Ruo-Lei; Mao Li-Bin; Xu Yao; Li Xiao-Fan; Wang Feng-Po; Luo Xue-Gang; Zhou Hao; He Hong-Peng; Wang Nan; Zhang Tong-Cun. Generation of insulin-producing cells from C3H10T1/2 mesenchymal progenitor cells. Gene. 2015 Feb 25. [Epub ahead of print]

12. Zhang, Rui(#)Wang, NanZhang, ManZhang, Li-NanGuo, Zhi-XiaLuo, Xue-GangZhou, HaoHe, Hong-PengZhang, Tong-CunRho/MRTF-A-Induced Integrin Expression Regulates Angiogenesis in Differentiated Multipotent Mesenchymal Stem Cells.Stem Cells Int20152015534758-534758

13. Xiang-Zhu Shu(#)Li-Nan ZhangRui ZhangCai-Jiao ZhangHong-Peng HeHao ZhouNan WangTong-Cun ZhangHistone acetyltransferase p300 promotes MRTF-A-mediates transactivation of VE-cadherin gene in human umbilical vein endothelial cellsGene20155631):17-235.

联系方式

办公地点:天津经济技术开发区第十三大街29号澳门威泥斯人,

邮政编码:300457

办公电话:022-60602099

真:022-60602298

Emailhehongpeng@tust.edu.cn